The Wee Wei Tee lab investigates the epigenetic mechanisms during normal development and disease pathogenesis. Epigenetic regulators help to establish cell-type specific gene expression patterns and maintain long-term cellular memory and identity. Together with transcription factors, they form the frontline mechanisms underlying developmental stability and cellular homeostasis. Accordingly, transcriptional and epigenetic dysregulations frequently contribute to the etiology of numerous human pathologies, including complex mutifactorial diseases such as cancer and neurological disorders.
Our goal is to work towards formulating a comprehensive understanding of the epigenetic basis of human diseases, and we seek to achieve this by interfacing basic mechanistic studies with translational research.
To this end, our laboratory employs various genomic tools to interrogate genome-wide changes in chromatin states during development and disease, and utilises varied experimental tools such as bioinformatics, gene-editing, biochemistry as well as animal models and cell-based screens to uncover disease mechanisms.
Our Lab is Supported by :