Publications


Lau ms, hu z, zhao x, tan ys, liu j, huang h, yeo cj, leong hf, grinchuk ov, chan jk, yan j, tee ww

Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription

Nature Communications 2023 Oct 13; 14(1): 6464, doi: 10.1038/s41467-023-42078-9


zhang j, hu z, chung hh, tian y, lau kw, ser z, lim yt, sobota rm, leong hf, chen bj, yeo cj, tan yxs, kang j, tan ekd, sou lf, mcclurg ul, lakshmanan m, vaiyapuri ts, raju a, wong esm, tergaonkar v, rajarethinam r, pathak e, tam wl, tan ey, tee ww

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis

Nature Communications 2023 Apr 28; 14(1): 2439, doi: 10.1038/s41467-023-38132-1


sou lf, hamer g, tee ww, vader g, mcclurg ul

Cancer and meiotic gene expression: Two sides of the same coin?

Current Topics in Developmental Biology 2023: 151: 43-68, doi: 10.1016/bs.ctdb.2022.06.002

PMID: 36681477 (Review)



tan yxs, zhang J, Tee ww

Epigenetic regulation of inflammatory signaling and inflammation-induced cancer

Frontiers in Cell and Developmental Biology 2022 Jun 8: 10: 931493. doi: 10.3389/fcell.2022.931493

PMID: 35757000 (Review)


low Y, tan EKD, Hu Z, TAN YXS, Tee WW

Transposable element dynamics and regulation during zygotic genome activation in mammalian embryos and embryonic stem cell model systems

Stem Cells International 2021 Oct 15: 2021: 1624669. doi: 10.1155/2021/1624669

PMID: 34691189 (Review)


HU Z, tan ekd, CHIA G, Tan H, Leong HF, Chen BJ, Lau MS, Tan KYS, Bi X, Yang D, Ho YS, Wu B, Bao S, Wong ESM, Tee WW

Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells


Nature Cell Biology 2020 Feb; 22(2): 175-186. doi: 10.1038/s41556-019-0453-8


Screen Shot 2019-12-30 at 5.24.39 PM.png

HH Tan and TEE WW

Committing the primordial germ cell: An updated molecular perspective

Wiley Interdisciplinary Reviews: Systems Biology and Medicine 2019 Jan; 11(1): e1436. doi: 10.1002/wsbm.1436

PMID: 30225862 (Review)


Hu Z and Tee WW

Enhancers and chromatin structures: regulatory hubs in gene expression and diseases


Bioscience Reports 2017 Apr 28; 37(2): BSR20160183. doi: 10.1042/BSR20160183
PMID: 28351896 (Review)


Whittaker DE, Riegman KL, Kasah S, Mohan C, Yu T, Sala BP, Hebaishi H, Caruso A, Marques AC, Michetti C, Smachetti ME, Shah A, Sabbioni M, Kulhanci O, Tee WW, Reinberg D, Scattoni ML, Volk H, McGonnell I, Wardle FC, Fernandes C, Basson MA

The chromatin remodeling factor CHD7 controls cerebellar development by regulating
reelin expression


Journal of Clinical Investigation 2017 Mar 1; 127(3): 874-887. doi: 10.1172/JCI83408


Oksuz O and Tee WW

Probing Chromatin Modifications in Response to ERK Signaling


Methods in Molecular Biology 2017;1487:289-301. doi: 10.1007/978-1-4939-6424-6_22


Tee WW* and Reinberg D*

Chromatin features and the epigenetic regulation of pluripotency states in ESCs


Development. Jun 2014;141(12):2376-90. doi: 10.1242/dev.096982. PMCID: PMC4050692
(*co-corresponding authors) (Review).


Tee WW, Shen SS, Oksuz O, Narendra V, Reinberg D

Erk1/2 Activity Promotes Chromatin Features and RNAPII Phosphorylation at Developmental Promoters in Mouse ESCs


Cell. Feb 2014;156(4):678-90. doi: 10.1016/j.cell.2014.01.009. PMCID: PMC4006806
(article highlighted in Nat Rev Mol Cell Biol. 2014 Apr;15(4):219. and in Science Signaling 7, ec63 (2014)).


Voigt P*, Tee WW*, Reinberg D

A double take on bivalent promoters


Genes & Development. Jun 2013;27(12):1318-38. doi: 10.1101/gad.219626.113
PMCID: PMC3701188
(*co-first authors) (Review)


Tee WW, Pardo M, Theunissen TW, Yu L, Choudhary JS, Hajkova P, Surani MA

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency


Genes & Development. Dec 2010;24(24):2772-7. doi: 10.1101/gad.606110
PMCID: PMC3003195
(article highlighted in Nat Rev Mol Cell Biol. 2011 Feb;12(2):76.)


Surani MA, Durcova-Hills G, Hajkova P, Hayashi K, Tee WW

Germ line, stem cells, and epigenetic reprogramming


Cold Spring Harbor symposia on quantitative biology. 2008;73:9-15.
doi: 10.1101/sqb.2008.73.015
(Review)


Asakawa K, Kume K, Kanai M, Goshima T, Miyahara K, Dhut S, Tee WW, Hirata, D, Toda, T

The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint


Molecular Biology of the Cell. Mar 2006;17(3):1421-35. doi: 10.1091/mbc.E05-08-0802
PMCID: PMC1382329